Lantos J, Marjai E
Acta Microbiol Acad Sci Hung. 1980;27(1):47-53.
Between 1976 and 1978, waves of Salmonella london infections conveyed by raw meat and meat products were observed. The strains isolated during the epidemic were first susceptible then developed multiple antibiotic resistance. The identical antibiotic resistance patterns of the strain and their more frequent occurrence in hospital environments indicated plasmid-mediated resistance. R-plasmid transfer, minimum inhibition concentration and resistance elimination were studied in representative strains. The resistant S. london strain and transconjugants of Escherichia coli rendered resistant were compared. The results proved that multiple resistance was plasmid-mediated.
1976年至1978年间，观察到由生肉和肉制品传播的伦敦沙门氏菌感染浪潮。疫情期间分离出的菌株最初是敏感的，随后出现了多重抗生素耐药性。菌株相同的抗生素耐药模式及其在医院环境中更频繁的出现表明是质粒介导的耐药性。对代表性菌株进行了R质粒转移、最低抑菌浓度和耐药性消除研究。比较了耐药的伦敦沙门氏菌菌株和获得耐药性的大肠杆菌转接合子。结果证明多重耐药是由质粒介导的。
