Pálfi V, Belák S
Acta Microbiol Acad Sci Hung. 1980;27(2):135-9.
Adenovirus vaccines inactivated and adsorbed with different methods were prepared for the specific control of pneumoenteritis of lambs. Beta-propiolactone and formalin as inactivating agents and aluminium hydroxide gel and DEAE dextran as adjuvants were compared. Vaccines inactivated and adsorbed in different ways provoked practically the same immunological response. Seronegative lambs developed a higher level of antibodies after the administration of monovalent vaccines, than in the case of a bivalent one. It is concluded that inactivated and adsorbed adenovirus vaccines provoke a significant production of antibodies in sheep.
制备了用不同方法灭活和吸附的腺病毒疫苗，用于特异性防治羔羊的肺炎肠炎。比较了用β-丙内酯和福尔马林作为灭活剂，以及用氢氧化铝凝胶和二乙氨基乙基葡聚糖作为佐剂的情况。以不同方式灭活和吸附的疫苗引发了几乎相同的免疫反应。血清阴性的羔羊在接种单价疫苗后产生的抗体水平高于接种双价疫苗的情况。得出的结论是，灭活和吸附的腺病毒疫苗能在绵羊体内引发显著的抗体产生。
