Deykin E Y, MacMahon B
Am J Dis Child. 1980 Sep;134(9):860-4. doi: 10.1001/archpedi.1980.02130210044012.
An investigation of the prenatal, delivery, and neonatal experience of 145 autistic children matched with 330 unaffected siblings revealed that among the propositi there was a preponderance of first-born children. Obstetrical records, which had been made prior to the diagnosis of autism, indicated that autistic children were more likely than their siblings to have experienced at least one untoward event during their mothers' gestations and deliveries. Similarly, the autistic children had an increased risk of neonatal complications. Despite the significant excess of total reproductive complications in the autistic series, there was no single event or a combination of biologically related complications that could reasonably account for any large number of cases of autism. While it is possible that autism may be the product of several diverse deleterious events experienced in utero, during delivery, or in the early neonatal period, our finding could be a chance occurrence or could signal the presence of a unknown factor responsible both for autism and for a variety of reproductive complications.
一项针对145名自闭症儿童及其330名未受影响的兄弟姐妹的产前、分娩及新生儿期经历的调查显示，在这些自闭症患儿中，头胎出生的孩子占多数。在自闭症诊断之前所做的产科记录表明，与他们的兄弟姐妹相比，自闭症儿童在其母亲孕期和分娩过程中更有可能经历至少一次不良事件。同样，自闭症儿童出现新生儿并发症的风险也更高。尽管自闭症患儿系列中总的生殖并发症显著增多，但没有任何单一事件或一系列生物学相关并发症能够合理地解释大量自闭症病例。虽然自闭症有可能是在子宫内、分娩过程中或新生儿早期经历的多种不同有害事件的产物，但我们的发现可能只是偶然现象，也可能表明存在一个未知因素，该因素既导致自闭症，又引发各种生殖并发症。
