Deb S, Prasad K B, Seth H, Eagles J M
Welsh Centre for Learning Disabilities, University of Wales College of Medicine, Cardiff, Wales.
J Intellect Disabil Res. 1997 Feb;41 ( Pt 1):81-6. doi: 10.1111/j.1365-2788.1997.tb00680.x.
Sixty-one children had a diagnosis of autistic disorder according to the DSM3-R criteria in a population based study of mentally retarded children between the ages of 5 and 19 years in the Aberdeen city area of Scotland. Obstetric case records were traced for 36 out of these 61 autistic children. The obstetric case records of siblings of 30 of these autistic children were also traced. Modified versions of Prechtl's obstetric optimality scale along with that of Parnas were used to score pre-, peri- and neonatal obstetric complications in the autistic group and their normal sibling controls. A Spearman's correlation coefficient test between the scores of the Childhood Autism Rating Scale (CARS) and the Obstetric and Neonatal Complication (ONC) scores of all autistic children did not reveal any significant correlation. However, among the 20 severe autistic children, Spearman's test showed significant correlation between the scores of CARS and some ONC scores. Overall, no statistically significant difference between the autistic children and their siblings in the scores of obstetric optimality was detected by using the Wilcoxon test.
在苏格兰阿伯丁市地区对5至19岁智障儿童进行的一项基于人群的研究中，根据DSM3-R标准，有61名儿童被诊断为自闭症谱系障碍。在这61名自闭症儿童中，找到了36名儿童的产科病例记录。还追踪了其中30名自闭症儿童兄弟姐妹的产科病例记录。使用Prechtl产科最优性量表以及Parnas量表的修改版，对自闭症组及其正常兄弟姐妹对照组的产前、围产期和新生儿产科并发症进行评分。对所有自闭症儿童的儿童自闭症评定量表（CARS）得分与产科和新生儿并发症（ONC）得分进行Spearman相关系数检验，未发现任何显著相关性。然而，在20名重度自闭症儿童中，Spearman检验显示CARS得分与一些ONC得分之间存在显著相关性。总体而言，使用Wilcoxon检验未发现自闭症儿童与其兄弟姐妹在产科最优性得分上有统计学显著差异。
