Lee T K, Man S F, Connolly T P, Noujaim A A
Am Rev Respir Dis. 1980 Mar;121(3):487-94. doi: 10.1164/arrd.1980.121.3.487.
We compared simultaneously measured canine tracheal transport rates of Dowex anion exchange particles with macroaggregates of albumin, and with sulfur colloid. We found that sulfur colloid moved significantly faster than large Dowex particles (diameter 180 micrometer), which had transport rates similar to macroaggregates of albumin, and small Dowex particles diameter 3 micrometer). We examined the alteration of airway fluid caused by intravenous 5% saline or subcutaneous methacholine chloride. We then studied the effects of the altered airway fluid on the transport rates of large Dowex particles and sulfur colloid. We found that sulfur colloid continued to be transported faster than Dowex particles. Although we do not have an explanation for the faster transport of sulfur colloid, we believe that the physiochemical properties of the marker may influence its rate of tracheal transport.
我们同时比较了用Dowex阴离子交换颗粒、白蛋白大聚集体和硫胶体测量的犬气管转运速率。我们发现硫胶体的移动速度明显快于大的Dowex颗粒（直径180微米），大的Dowex颗粒的转运速率与白蛋白大聚集体以及小的Dowex颗粒（直径3微米）相似。我们研究了静脉注射5%盐水或皮下注射氯化乙酰甲胆碱引起的气道液体变化。然后，我们研究了气道液体变化对大Dowex颗粒和硫胶体转运速率的影响。我们发现硫胶体的转运速度仍然快于Dowex颗粒。虽然我们无法解释硫胶体转运更快的原因，但我们认为标志物的物理化学性质可能会影响其气管转运速率。
