Bower J S, Belen J E, Weg J G, Dantzker D R
Am Rev Respir Dis. 1980 Aug;122(2):325-32. doi: 10.1164/arrd.1980.122.2.325.
Sarcoidosis involving the larynx presents with hoarseness, cough, dysphagia, and dyspnea secondary to upper airway obstruction. it may occur in patients with previously diagnosed sarcoidosis, or it may be the first or the only manifestation of the disease. Laryngoscopy reveals mucosal alterations including erythema and edema, punctate nodules, and mass lesions. The epiglottis is the most frequently affected area, but any portion of the larynx may be involved. The diagnosis is established by demonstrating granulomatous inflammation on laryngeal biopsy and excluding other causes of granulomatous laryngitis. Systemic corticosteroid therapy is the treatment of choice in most cases, but local steroid injection or surgical excision of affected areas may be useful in selected patients. Symptomatic laryngeal sarcoidosis can be managed successfully, but if it is left untreated, life-threatening upper airway obstruction may occur.
累及喉部的结节病表现为声音嘶哑、咳嗽、吞咽困难以及继发于上气道梗阻的呼吸困难。它可能发生在先前已确诊结节病的患者中，也可能是该疾病的首发或唯一表现。喉镜检查显示黏膜改变，包括红斑、水肿、点状结节和肿块病变。会厌是最常受累的部位，但喉部的任何部分都可能受累。通过喉部活检显示肉芽肿性炎症并排除肉芽肿性喉炎的其他病因来确立诊断。在大多数情况下，全身糖皮质激素治疗是首选治疗方法，但局部类固醇注射或对受累区域进行手术切除对某些患者可能有用。有症状的喉部结节病可以成功治疗，但如果不治疗，可能会发生危及生命的上气道梗阻。
