Jakse R, Fleischmann G
HNO. 1985 Mar;33(3):118-23.
The larynx may be involved in patients with systemic sarcoidosis or may be the first or only manifestation of the disease. The symptoms depend on the degree of involvement of the larynx, and include a sensation of lump in the throat, dysphagia, hoarseness, cough, stridor and dyspnea. The supraglottis is the most frequently affected area. There are pale pink, edematous, diffuse hypertrophy of the supraglottic structures or granular areas of the glottic and subglottic region. The diagnosis is made by the characteristic appearance of the larynx, histologic and laboratory findings and exclusion of other granulomatous diseases. Laryngeal sarcoidosis may cause life-threatening upper airway obstruction. Systemic corticosteroid therapy is the treatment of choice in most cases, but surgical excision or local steroid injections are useful in selected cases.
喉可能累及全身性结节病患者，也可能是该病的首发或唯一表现。症状取决于喉的受累程度，包括咽部异物感、吞咽困难、声音嘶哑、咳嗽、喘鸣和呼吸困难。声门上区是最常受累的部位。可见声门上结构呈淡粉红色、水肿、弥漫性肥大，或声门及声门下区有颗粒状区域。根据喉部的特征性表现、组织学和实验室检查结果以及排除其他肉芽肿性疾病来做出诊断。喉结节病可导致危及生命的上气道梗阻。在大多数情况下，全身糖皮质激素治疗是首选治疗方法，但在某些特定病例中，手术切除或局部注射类固醇是有效的。
