Stevenaert A, Chiodera P, Legros J J, Copinschi G, Franchimont P
Ann Endocrinol (Paris). 1980 May-Jun;41(3):249-50.
Forty acromegalic patients were investigated before, during and after transsphenoidal selective adenomectomy. Pre- and post-operative studies were based on HGH basal levels, OGTT, TRH and LRH stimulation tests, while HGH plasma variations were measured during operation. Selective adenomectomy normalized HGH levels in 70% of all cases (89.5% in grades I-II and 52.4% in grades III-IV); moreover in these cases, OGTT documented normal control of GH secretion. Per-operative GH levels evolution proved to be of pronostic value. Stimulation tests demonstrated normal regulation of other pituitary functions.
对40例肢端肥大症患者在经蝶窦选择性腺瘤切除术前、术中和术后进行了研究。术前和术后研究基于生长激素基础水平、口服葡萄糖耐量试验（OGTT）、促甲状腺激素释放激素（TRH）和促黄体生成素释放激素（LRH）刺激试验，同时在手术期间测量血浆生长激素的变化。选择性腺瘤切除术使70%的病例生长激素水平恢复正常（I-II级为89.5%，III-IV级为52.4%）；此外，在这些病例中，OGTT显示生长激素分泌得到正常控制。术中生长激素水平的变化被证明具有预后价值。刺激试验表明其他垂体功能调节正常。
