Bol'shakov I N, Poberiĭ I A, Lindner D P, Zubkov B A, Panasiuk A V
Arkh Patol. 1980;42(5):26-32.
Phytohemagglutinin (PHA) produced by Difco, USA, (3.3 microgram per 1 mg of unguentum base) was tested as a stimulator of the healing of suppurative skin-muscle wounds 4 cm2 in area in 70 rabbits divided into 3 groups according to reaction to the intracutaneous test with PHA. Enhanced wound healing was observed only in poorly reacting rabbits (20.7 against 31.1 days in control). A considerable increase in the number of activated lymphocytes and cells of monocyte-macrophage group in the wound exudate, increased phagocytosis as well as more rapid and intensive development of proliferative processes were also established. The stimulation mechanism includes the direct PHA effect on inflammation cells and epithelium and a complex chain of both direct and mediated cellular interactions.
美国迪夫科公司生产的植物血凝素（PHA，每1毫克软膏基质含3.3微克）作为一种刺激剂，用于测试其对70只家兔面积为4平方厘米的化脓性皮肤肌肉伤口愈合的作用。这些家兔根据对PHA皮内试验的反应分为3组。仅在反应较差的家兔中观察到伤口愈合加快（20.7天，而对照组为31.1天）。伤口渗出液中活化淋巴细胞和单核细胞 - 巨噬细胞组细胞数量显著增加，吞噬作用增强，增殖过程发展更快且更强烈。刺激机制包括PHA对炎症细胞和上皮的直接作用以及直接和介导的细胞相互作用的复杂链条。
