Lindner D P, Poberiĭ I A, Bol'shakov I N
Biull Eksp Biol Med. 1982 Mar;93(3):106-10.
Altogether 165 rabbits were distributed into strongly and poorly reacting groups in terms of delayed type hypersensitivity (DTH) to phytohemagglutinin (PHA). It was established that leukocyte response to wound process correlated with the intensity of DTH. The strongly reacting animals manifested of DTH. The strongly reacting animals manifested an adequate response (leukocytosis, neutrophilosis, nomocytosis, lymphocytosis, a decrease in myeloperoxidase and enhancement of phagocytic activity of neutrophils), while the poorly responding animals an in adequate one (passivity of the leukocytic parameters with the exception of monocytosis). Application of the liniment containing PHA (3.3 micrograms per g base, Difco, USA) does not change the response in the strongly reacting animals and essentially corrects all the leukocytic parameters in the poorly reacting animals with the exception of phagocytic activity of neutrophils. From the leukocytic response pattern a conclusion is made about multiple defect of the leukocytic system under poor DTH to PHA and about the leading role of monocytes in correcting the defect by PHA.
总共165只兔子根据对植物血凝素（PHA）的迟发型超敏反应（DTH）被分为强反应组和弱反应组。结果表明，白细胞对伤口过程的反应与DTH的强度相关。强反应动物表现出DTH。强反应动物表现出适当的反应（白细胞增多、中性粒细胞增多、核左移、淋巴细胞增多、髓过氧化物酶减少以及中性粒细胞吞噬活性增强），而弱反应动物则表现出不适当的反应（除单核细胞增多外，白细胞参数无变化）。应用含PHA的搽剂（每克基质含3.3微克，美国Difco公司）对强反应动物的反应无影响，但能基本纠正弱反应动物的所有白细胞参数，除了中性粒细胞的吞噬活性。从白细胞反应模式可以得出结论，对PHA的DTH较弱时，白细胞系统存在多种缺陷，且单核细胞在PHA纠正缺陷中起主导作用。
