Lindner D P, Bol'shakov I N, Poberiĭ I A, Stetsenko O N
Arkh Patol. 1982;44(11):30-8.
Principal differences in wound healing were established in rabbits with weak and strong delayed type hypersensitivity (DTH) to phytohemagglutinin (PHA). The evaluation included the rate of contraction of the wound defect, macroscopic control, cytology of the wound exudate, qualitative and quantitative histology. The rate of healing in strong DTH to PHA is 1 1/2 times as high and the death-rate of wound infection 2 times as low as in weak DTH. The response of immunity organs (thymus, spleen, regional lymph node) and peripheral blood leukocytes was also found to differ significantly despite their initial structural homogeneity. Comparison of the experimental data with the results of a similar study of selective therapeutic effect of PHA on wound healing in low DTH leads to a conclusion of the greatest intactness of the monocytic macrophage system, its leading role in correction of healing, as well as of the greatest defects in the neutrophil system.
在对植物血凝素（PHA）具有弱和强迟发型超敏反应（DTH）的兔子中，发现了伤口愈合的主要差异。评估包括伤口缺损的收缩率、宏观检查、伤口渗出液的细胞学检查、定性和定量组织学检查。对PHA具有强DTH的愈合率是弱DTH的1.5倍，伤口感染死亡率是弱DTH的一半。尽管免疫器官（胸腺、脾脏、局部淋巴结）和外周血白细胞最初结构相同，但也发现它们的反应存在显著差异。将实验数据与PHA对低DTH伤口愈合的选择性治疗效果的类似研究结果进行比较，得出单核巨噬细胞系统最完整、其在愈合校正中起主导作用以及中性粒细胞系统存在最大缺陷的结论。
