Godel V, Nemet P, Lazar M
Arch Ophthalmol. 1980 Aug;98(8):1417-21. doi: 10.1001/archopht.1980.01020040269011.
Three patients with cystic fibrosis of the pancreas initially were seen because of optic neuropathy caused by a toxic reaction to chloramphenicol. The ocular symptoms were characterized by loss of visual acuity, central scotomas, red-green dyschromatopsia, and fundus changes. An increase in the latency of the occipital evoked potentials paralleled the visual impairment. A transient photopic decline in the red-light-elicited electroretinogram and the occurrence of Uhthoff's sign in the acute stage of the disease were observed. All visual impairment recovered partially or totally after the withdrawal of therapy with the drug.
三名胰腺囊性纤维化患者最初因对氯霉素的毒性反应导致视神经病变而就诊。眼部症状的特征为视力丧失、中心暗点、红绿色觉异常和眼底改变。枕叶诱发电位潜伏期的增加与视力损害平行。在疾病急性期观察到红光诱发的视网膜电图出现短暂的明视觉下降以及Uhthoff征。停用该药物治疗后，所有视力损害均部分或完全恢复。
