[System regulating lipid oxidation and the state of the nuclear membrane during tumor growth].

Changes of antioxidative activity (AOA), lipid composition and membrane structure in tumour cell nuclei and in the liver of tumour-carrier during the development of Ehrlich ascite carcinoma (EAC) were studied. On the basis of the data obtained the work of physico-chemical system of oxidative reactions in lipids was analysed. This control system involves a relationship between AOA changes, lipid composition, their oxidative ability and the nuclear membrane structure. It was shown that with EAC development in the cell nuclei of the tumour-carrier liver the control system under study is functioning like in the normal state. In EAC cell nuclei in the course of tumour growth there proceeds a change in the relationship AOA -- lipid composition -- membrane structure, the primary disturbance in the system appearing evidently within the link AOA -- lipid composition.