Burlakova E B, Mal'tseva E L, Goloshchapov A N, Pal'mina N P
Biofizika. 1980 Sep-Oct;25(5):859-64.
Changes of antioxidative activity (AOA), lipid composition and membrane structure in tumour cell nuclei and in the liver of tumour-carrier during the development of Ehrlich ascite carcinoma (EAC) were studied. On the basis of the data obtained the work of physico-chemical system of oxidative reactions in lipids was analysed. This control system involves a relationship between AOA changes, lipid composition, their oxidative ability and the nuclear membrane structure. It was shown that with EAC development in the cell nuclei of the tumour-carrier liver the control system under study is functioning like in the normal state. In EAC cell nuclei in the course of tumour growth there proceeds a change in the relationship AOA -- lipid composition -- membrane structure, the primary disturbance in the system appearing evidently within the link AOA -- lipid composition.
研究了艾氏腹水癌（EAC）发展过程中肿瘤细胞核及荷瘤小鼠肝脏中抗氧化活性（AOA）、脂质组成和膜结构的变化。根据所得数据，分析了脂质氧化反应物理化学系统的作用。该控制系统涉及AOA变化、脂质组成、其氧化能力和核膜结构之间的关系。结果表明，随着荷瘤小鼠肝脏细胞核中EAC的发展，所研究的控制系统在正常状态下发挥作用。在肿瘤生长过程中的EAC细胞核中，AOA-脂质组成-膜结构之间的关系发生了变化，系统中的主要干扰显然出现在AOA-脂质组成这一环节。
