成年大鼠脑中谷胱甘肽还原酶的区域分布。

Regional distribution of glutathione reductase in the adult rat brain.

作者信息

Brannan T S, Maker H S, Raes I, Weiss C

出版信息

Brain Res. 1980 Nov 3;200(2):474-7. doi: 10.1016/0006-8993(80)90936-1.

Abstract

Glutathione reductase was measured in 10 selected areas of the adult rat brain. Activitives varied over a 2.5-fold range. The caudate-putamen and cortical areas contained the highest activities. Several gray matter structures contained intermediate activities. The substantia nigra and the corpus callosum, a white matter structure, contained the lowest activities. The caudate-putamen, a catecholamine rich area, may produce H2O2 via MAO and would require glutathione reductase to recycle glutathione oxidized by glutathione peroxidase. However, the distribution of glutathione reductase activity also suggests a role in reducing oxidants formed during tissue respiration.

摘要

在成年大鼠大脑的10个选定区域测量了谷胱甘肽还原酶。活性在2.5倍的范围内变化。尾状核-壳核和皮质区域的活性最高。几个灰质结构的活性处于中等水平。黑质和胼胝体（一种白质结构）的活性最低。尾状核-壳核是富含儿茶酚胺的区域，可能通过单胺氧化酶产生过氧化氢，并且需要谷胱甘肽还原酶来循环由谷胱甘肽过氧化物酶氧化的谷胱甘肽。然而，谷胱甘肽还原酶活性的分布也表明其在还原组织呼吸过程中形成的氧化剂方面发挥作用。