Brannan T S, Maker H S, Raes I P
J Neurochem. 1981 Jan;36(1):307-9. doi: 10.1111/j.1471-4159.1981.tb02411.x.
Catalase activity was measured in 11 areas of perfused adult rat brain. The hypothalamus and substantia nigra contained the highest activities. The corpus callosum, a white-matter structure, contained intermediate activity. The caudate-putamen and frontal cortex contained the lowest activities. Regional catalase bears some relationship to the reported distribution of microperoxisomes, but considerable activity is present in areas with few microperoxisomes. Catalase may function as one of the systems detoxifying H2O2 formed in CNS amine metabolism.
在成年大鼠灌注脑的11个区域测量了过氧化氢酶活性。下丘脑和黑质的活性最高。胼胝体作为一种白质结构，活性处于中等水平。尾状核-壳核和额叶皮质的活性最低。区域过氧化氢酶与报道的微过氧化物酶体分布有一定关系，但在微过氧化物酶体较少的区域也存在相当高的活性。过氧化氢酶可能作为中枢神经系统胺代谢中产生的过氧化氢解毒系统之一发挥作用。
