[S-腺苷甲硫氨酸和S-腺苷同型半胱氨酸对大鼠脑不同部位去甲肾上腺素和5-羟色胺体内合成的影响]
[Effects of S-adenosylmethionine and S-adenosylhomocysteine on in vivo synthesis of noradrenaline and serotonin in different parts of the rat brain].
作者信息
Fonlupt P, Barailler J, Roche M, Cronenberger L, Pacheco H
出版信息
C R Seances Acad Sci D. 1979 Jan 15;288(2):283-6.
PMID:111855
Abstract
S-adenosylmethionine (0,1 mg/kg/ip) decreases in vivo, norepinephrine (NE) synthesis and does not affect 5-hydroxytryptamine (5 HT) synthesis in the Rat brain. S-adenosylhomocysteine (7 mg/kg/ip) increases NE synthesis and decreases 5 HT synthesis. Neither nucleoside affects dopamine synthesis.
摘要
S-腺苷甲硫氨酸（0.1毫克/千克，腹腔注射）可降低大鼠脑内去甲肾上腺素（NE）的合成，且不影响5-羟色胺（5-HT）的合成。S-腺苷高半胱氨酸（7毫克/千克，腹腔注射）可增加NE的合成并减少5-HT的合成。两种核苷均不影响多巴胺的合成。
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