Sibbald B
Clin Allergy. 1980 May;10(3):313-8. doi: 10.1111/j.1365-2222.1980.tb02113.x.
The distributions of asthma, hay fever and eczema were examined in the first degree relatives of 516 asthmatics grouped according to atopic status, history of hay fever/eczema and history of asthma provoked by pollens, dust or animals. The prevalences of both asthma and eczema in relatives were strongly correlated with the presence of hay fever/eczema in probands and to a lesser extent with their atopic status. The prevalence of hay fever in relatives was strongly correlated with both the presence of hay fever/eczema and the degree of atopy in probands. In contrast, allergic provocation of asthma in probands did not influence the prevalences of asthma, hay fever or eczema. These findings are consistent with the hypothesis that there is an increased risk of asthma in relatives of atopic asthmatics which may arise from the enhanced susceptibility to asthma of individuals who inherit both a predisposition to asthma and a predisposition to atopy.
根据特应性状态、花粉症/湿疹病史以及花粉、灰尘或动物诱发的哮喘病史，对516名哮喘患者的一级亲属进行分组，研究哮喘、花粉症和湿疹的分布情况。亲属中哮喘和湿疹的患病率与先证者中花粉症/湿疹的存在密切相关，与他们的特应性状态相关性较小。亲属中花粉症的患病率与先证者中花粉症/湿疹的存在以及特应性程度密切相关。相比之下，先证者中哮喘的变应性激发并不影响哮喘、花粉症或湿疹的患病率。这些发现与以下假设一致，即特应性哮喘患者的亲属患哮喘的风险增加，这可能是由于继承了哮喘易感性和特应性倾向的个体对哮喘的易感性增强所致。
