儿童哮喘中的遗传因素。
Genetic factors in childhood asthma.
作者信息
Sibbald B, Horn M E, Brain E A, Gregg I
出版信息
Thorax. 1980 Sep;35(9):671-4. doi: 10.1136/thx.35.9.671.
The prevalences of asthma and atopy were examined in the families of 77 asthmatic and 87 control children attending a London general practice. The prevalence of asthma in first degree relatives of asthmatic children was found to be significantly higher than in relatives of control children, and this difference was more pronounced for relatives of atopic probands than for relatives of non-atopic probands. Among the relatives of asthmatics, atopic asthma was more common than non-atopic asthma, irrespective of the atopic status of the proband. However, among the relatives of control children, neither the prevalence of asthma nor the atopic status of the asthmatic relatives was influenced by the atopic status of the proband. These findings support the hypothesis that asthma and atopy are inherited independently. Although atopy itself does not predispose to asthma, it may enhance a genetic susceptibility to the condition, thus increasing the likelihood that the latter will be expressed.
对伦敦一家普通诊所的77名哮喘儿童和87名对照儿童的家庭进行了哮喘和特应性疾病患病率的调查。结果发现，哮喘儿童一级亲属中哮喘的患病率显著高于对照儿童的亲属，并且这种差异在特应性先证者的亲属中比特应性非先证者的亲属中更为明显。在哮喘患者的亲属中，无论先证者的特应性状态如何，特应性哮喘比非特应性哮喘更为常见。然而，在对照儿童的亲属中，先证者的特应性状态既不影响哮喘的患病率，也不影响哮喘亲属的特应性状态。这些发现支持了哮喘和特应性疾病是独立遗传的假说。虽然特应性本身不会诱发哮喘，但它可能会增强对该疾病的遗传易感性，从而增加哮喘发病的可能性。
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