豚鼠严重实验性变应性脑脊髓炎中的亚油酸疗法：持续治疗的抑制作用
Linoleic acid therapy in severe experimental allergic encephalomyelitis in the guinea-pig: suppression by continuous treatment.
作者信息
Hughes D, Keith A B, Mertin J, Caspary E A
出版信息
Clin Exp Immunol. 1980 Jun;40(3):523-31.
Abstract
The effect of oral linoleic acid (LA) treatment on experimental allergic encephalomyelitis (EAE) in guinea-pigs in three trials of differing disease intensity has been investigated. The efficacy of LA treatment was linked to the severity of the disease being suppressed. The trial with the greatest disease severity showed no beneficial effect. The other two trials with less severe disease showed a marked therapeutic response to LA, but only when treatment was started before immunization and given continuously. This was apparent in both clinical and histopathological responses. These results support an immunoregulatory mechanism for LA treatment in EAE and by analogy in multiple sclerosis.
摘要
在三项疾病强度不同的试验中，研究了口服亚油酸（LA）治疗对豚鼠实验性变应性脑脊髓炎（EAE）的影响。LA治疗的疗效与所抑制疾病的严重程度相关。疾病严重程度最高的试验未显示出有益效果。另外两项疾病不太严重的试验显示，LA有显著的治疗反应，但仅当在免疫前开始治疗并持续给药时才有效。这在临床和组织病理学反应中均很明显。这些结果支持了LA治疗EAE的免疫调节机制，同理也适用于多发性硬化症。
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