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2
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Multiple sclerosis.多发性硬化症
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The EAE Model: A Tentative Connection to Multiple Sclerosis.实验性自身免疫性脑脊髓炎模型：与多发性硬化症的初步联系
Science. 1977 Mar 11;195(4282):969-71. doi: 10.1126/science.195.4282.969.
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Multiple sclerosis; a correlation of its incidence with dietary fat.多发性硬化症；其发病率与膳食脂肪的相关性。
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AN ENCEPHALITOGENIC PROTEIN OF HUMAN ORIGIN: SOME CHEMICAL AND BIOLOGICAL PROPERTIES.一种人类源致脑炎蛋白：一些化学和生物学特性
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Deficiency of essential fatty acids and atherosclerosis, etcetera.必需脂肪酸缺乏与动脉粥样硬化等。
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A biochemical approach to the problem of multiple sclerosis.一种针对多发性硬化症问题的生化方法。
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6
Allergic encephalomyelitis induced by brain antigen after deficiency in polyunsaturated fatty acids during myelination.髓鞘形成过程中多不饱和脂肪酸缺乏后由脑抗原诱导的变应性脑脊髓炎。
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
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[Negative results following use of indomethacin in treatment of multiple sclerosis].[使用吲哚美辛治疗多发性硬化症后的阴性结果]
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Double-blind trial of linoleate supplementation of the diet in multiple sclerosis.饮食中补充亚油酸对多发性硬化症的双盲试验。
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Oleic acid as a depressant of reticuloendothelial activity in rats and mice.油酸作为大鼠和小鼠网状内皮系统活性的抑制剂。
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豚鼠严重实验性变应性脑脊髓炎中的亚油酸疗法：持续治疗的抑制作用

Linoleic acid therapy in severe experimental allergic encephalomyelitis in the guinea-pig: suppression by continuous treatment.

作者信息

Hughes D, Keith A B, Mertin J, Caspary E A

出版信息

Clin Exp Immunol. 1980 Jun;40(3):523-31.

PMID:7418264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538940/
Abstract

The effect of oral linoleic acid (LA) treatment on experimental allergic encephalomyelitis (EAE) in guinea-pigs in three trials of differing disease intensity has been investigated. The efficacy of LA treatment was linked to the severity of the disease being suppressed. The trial with the greatest disease severity showed no beneficial effect. The other two trials with less severe disease showed a marked therapeutic response to LA, but only when treatment was started before immunization and given continuously. This was apparent in both clinical and histopathological responses. These results support an immunoregulatory mechanism for LA treatment in EAE and by analogy in multiple sclerosis.

摘要

在三项疾病强度不同的试验中，研究了口服亚油酸（LA）治疗对豚鼠实验性变应性脑脊髓炎（EAE）的影响。LA治疗的疗效与所抑制疾病的严重程度相关。疾病严重程度最高的试验未显示出有益效果。另外两项疾病不太严重的试验显示，LA有显著的治疗反应，但仅当在免疫前开始治疗并持续给药时才有效。这在临床和组织病理学反应中均很明显。这些结果支持了LA治疗EAE的免疫调节机制，同理也适用于多发性硬化症。