Winterbauer R H, Hutchinson J F
Chest. 1980 Oct;78(4):640-7. doi: 10.1378/chest.78.4.640.
The literature on pulmonary function testing in sarcoidosis is critically reviewed. The results indicate that pulmonary function tests are not a reliable means for detecting the presence of parenchymal sarcoidosis, nor do they provide an accurate estimate of the extent of parenchymal disease. There are at present no known pulmonary function criteria that allow the clinician to predict the natural cause of pulmonary sarcoidosis or the response to therapy. The major value of pulmonary function testing is to assess changes in the disease course of the individual patient through sequential measurements. Currently there is no conclusive evidence that measurements of arterial blood gas tensions or pulmonary compliance add significantly to the sensitivity and specificity of the vital capacity and diffusing capacity in the management of sarcoidosis.
本文对结节病肺功能测试的相关文献进行了批判性综述。结果表明，肺功能测试并非检测实质性结节病存在的可靠手段，也无法准确评估实质性疾病的程度。目前尚无已知的肺功能标准能让临床医生预测肺结节病的自然病程或对治疗的反应。肺功能测试的主要价值在于通过连续测量来评估个体患者疾病进程的变化。目前尚无确凿证据表明，在结节病的管理中，动脉血气张力或肺顺应性的测量能显著提高肺活量和弥散量的敏感性和特异性。
