Distribution of gentamicin and amikacin in rabbit tissues.
作者信息
Kornguth M L, Kunin C M
出版信息
Antimicrob Agents Chemother. 1977 Jun;11(6):974-7. doi: 10.1128/AAC.11.6.974.
Abstract
Rabbits were injected intramuscularly with gentamicin and amikacin (15 mg of base per kg), and the antibiotic levels in tissues were determined 20 h after either a single or multiple injections. Disk diffusion assays, with Bacillus subtilis ATCC 6633, were carried out both on homogenates and on supernatants deproteinized with trichloroacetic acid. Both assays indicated that the kidney is the major site of antibiotic deposition. Antibiotic levels increased after multiple doses. Gentamicin levels in other tissues were higher than those of amikacin. The assay of trichloroacetic acid-treated material was more sensitive than the assay of the total homogenate.
摘要
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
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J Infect Dis. 1971 Dec;124 Suppl:S90-5. doi: 10.1093/infdis/124.supplement_1.s90.
3
Pharmacology of amikacin in humans.
Antimicrob Agents Chemother. 1974 May;5(5):508-12. doi: 10.1128/AAC.5.5.508.
4
Renal parenchymal accumulation of aminoglycoside antibiotics in rats.
J Infect Dis. 1974 Dec;130(6):656-9. doi: 10.1093/infdis/130.6.656.
5
Binding of antibiotics to tissue homogenates.
J Infect Dis. 1970 Jan;121(1):55-64. doi: 10.1093/infdis/121.1.55.
6
Comparative pharmacokinetics of amikacin and kanamycin.
Clin Pharmacol Ther. 1974 Jun;15(6):610-6. doi: 10.1002/cpt1974156610.
7
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