Seal A M, Debas H T
Gastroenterology. 1980 Nov;79(5 Pt 1):823-6.
The colon has been shown to contain an abundance of endocrine cells. Their role is not yet understood. In four dogs prepared with chronic gastric fistula and colonic fistula in the cecum the effects on pentagastrin dose responses of colonic perfusion with the following substance were studied: saline, 15% liver extract pH 7.0; sodium oleate pH 9.4; and 0.08 M HCl. The responses obtained in each of the perfusion studies were compared with those obtained without colonic perfusion. Whereas saline had no effect on these responses, liver extract, sodium oleate, and HCl, each produced significant inhibition. These results suggest that the colon has the capacity for inhibiting gastric acid secretion by some mechanism which may prove to be humoral. Until now the colon has rarely been considered in any assessment of the gut functioning as an endocrine organ. Perhaps a colonic endocrine role should now be given further consideration.
结肠已被证明含有大量内分泌细胞。它们的作用尚不清楚。在四只制备了慢性胃瘘和盲肠结肠瘘的狗身上，研究了用以下物质结肠灌注对五肽胃泌素剂量反应的影响：生理盐水、pH 7.0的15%肝提取物；pH 9.4的油酸钠；以及0.08 M盐酸。将每项灌注研究中获得的反应与未进行结肠灌注时获得的反应进行比较。生理盐水对这些反应没有影响，而肝提取物、油酸钠和盐酸均产生了显著抑制作用。这些结果表明，结肠具有通过某种可能被证明是体液性的机制抑制胃酸分泌的能力。到目前为止，在对作为内分泌器官的肠道功能进行的任何评估中，结肠很少被考虑。也许现在应该进一步考虑结肠的内分泌作用。
