Fahrenholz F, Thierauch K H
Int J Pept Protein Res. 1980 Apr;15(4):323-30. doi: 10.1111/j.1399-3011.1980.tb02908.x.
For the synthesis of p-azidophenylalanine peptides, the p-amino group of p-amino-L-phenylalanine is protected with the Z- or Boc residue via the copper complex or by specific acylation at pH 4.6. The alpha-amino or alpha-carboxy group is blocked by a protecting group (Boc, Ddz, OMe respectively Z, Nps, Ddz), which can be removed selectively. The synthesis of nine derivatives of p-amino-L-phenylalanine for incorporation into the peptide chain is described. The p-amino-phenylalanine is converted to p-azidophenylalanine without affecting disulfide bridges.
对于对叠氮基苯丙氨酸肽的合成，对氨基-L-苯丙氨酸的对氨基通过铜络合物或在pH 4.6下进行特定酰化反应，用Z-或Boc残基进行保护。α-氨基或α-羧基被保护基团（分别为Boc、Ddz、OMe或Z、Nps、Ddz）封闭，这些保护基团可被选择性去除。描述了用于掺入肽链的九种对氨基-L-苯丙氨酸衍生物的合成。对氨基苯丙氨酸在不影响二硫键的情况下转化为对叠氮基苯丙氨酸。
