以樟脑磺内酰胺或D-缬氨酸作为手性助剂合成对膦酰甲基-L-苯丙氨酸及其整合到整合素序列中。
Synthesis of p-phosphonomethyl-L-phenylalanine using camphor sultam or D-valine as chiral auxiliaries and its incorporation into integrin sequences.
作者信息
Larsson E, Lüning B
机构信息
Department of Organic Chemistry, Arrhenius Laboratories, Stockholm University, Sweden.
出版信息
Acta Chem Scand (Cph). 1996 Jan;50(1):54-7. doi: 10.3891/acta.chem.scand.50-0054.
Abstract
The synthesis of N-Boc-p-phosphonomethyl-L-phenylalanine with two different chiral auxiliaries, camphor sultam or D-valine is described. The preparations have essentially identical properties and have been used to incorporate the amino acid into two integrin peptides as non-hydrolyzable isosteres of phosphotyrosine.
摘要
描述了用两种不同的手性助剂（樟脑磺内酰胺或D-缬氨酸）合成N-叔丁氧羰基-p-膦酰甲基-L-苯丙氨酸。这些制备物具有基本相同的性质，并已用于将该氨基酸作为磷酸酪氨酸的不可水解等排体掺入两种整合素肽中。
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