Fc和C3受体依赖性人单核细胞吞噬作用的可溶性免疫复合物的效应
Effect of soluble immune complexes of Fc and C3 receptor-dependent phagocytosis by human monocytes.
作者信息
Kávai M, Sándor M, Szegedi G, Füst G, Gergely J
出版信息
Immunology. 1981 Nov;44(3):599-606.
The capacity was studied of bovine serum albumin (BSA) rabbit anti-BSA and ovalbumin (OA) rabbit anti-OA immune complexes of different composition to inhibit the Fc receptor-dependent adherence and phagocytosis of sensitized sheep red blood cells by human monocytes. Parallel experiments were performed on the ability of the immune but complement-reacted complexes to inhibit the C3 receptor-dependent phagocytosis of C3-coated yeast particles. The extent of inhibition of both the Fc and C3 receptor-dependent phagocytosis was proportional to the antibody avidity of the complex used. Immune complexes made at equivalence and at moderate antibody excess markedly inhibited both types of phagocytosis, whereas those made at moderate antigen excess had only a weak inhibitory effect. These findings can be explained by the correlation between the Fc receptor-binding and complement-activating capacities of immune complexes of different composition. An alternative explanation, however, is also discussed.
研究了不同组成的牛血清白蛋白（BSA）兔抗BSA和卵清蛋白（OA）兔抗OA免疫复合物抑制人单核细胞对致敏绵羊红细胞的Fc受体依赖性黏附及吞噬作用的能力。针对免疫但补体反应复合物抑制C3包被酵母颗粒的C3受体依赖性吞噬作用的能力进行了平行实验。Fc和C3受体依赖性吞噬作用的抑制程度与所用复合物的抗体亲和力成正比。等当量和适度抗体过量时形成的免疫复合物显著抑制两种吞噬作用，而适度抗原过量时形成的免疫复合物只有微弱的抑制作用。这些发现可以通过不同组成的免疫复合物的Fc受体结合能力与补体激活能力之间的相关性来解释。然而，也讨论了另一种解释。
Zotero 插件