卵磷脂对弗里德赖希共济失调患者残疾程度及血浆游离胆碱水平的影响。
Effect of lecithin on disability and plasma free-choline levels in Friedreich's ataxia.
作者信息
Chamberlain S, Robinson N, Walker J, Smith C, Benton S, Kennard C, Swash M, Kilkenny B, Bradbury S
出版信息
J Neurol Neurosurg Psychiatry. 1980 Sep;43(9):843-5. doi: 10.1136/jnnp.43.9.843.
Four patients with Friedreich's ataxia took part in an open trial, in which they consumed 50-100g/day lecithin granules (containing approximately 22% phosphatidycholine) for 16 weeks, but no improvement resulted. Several unwanted effects including diarrhoea, nausea, depression, "hot flushes" and weakness were experienced. Resting levels of free-choline in plasma were within the range found in 19 normal subjects. Sixteen other patients with Friedreich's ataxia also had normal free-choline levels. Treatment with lecithin significantly increased plasma free-choline levels, but there was a trend for these to fall towards baseline levels, despite continued ingestion of lecithin.
四名弗里德赖希共济失调患者参与了一项开放试验，他们连续16周每天服用50 - 100克卵磷脂颗粒（约含22%磷脂酰胆碱），但未出现病情改善。出现了一些不良反应，包括腹泻、恶心、抑郁、“潮热”和虚弱。血浆中游离胆碱的静息水平在19名正常受试者的范围内。另外16名弗里德赖希共济失调患者的游离胆碱水平也正常。卵磷脂治疗显著提高了血浆游离胆碱水平，但尽管持续摄入卵磷脂，这些水平仍有降至基线水平的趋势。
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