Barbeau A
Can J Neurol Sci. 1978 Feb;5(1):157-60.
This review evaluates the theoretical background and experimental data behind a new development: the replacement therapy of deficient central cholinergic systems with the dietary precursors choline or lecithin. Cholinergic deficiency states are possibly present in five neurological entities: Huntington's chorea, Tardive Dyskinesia, Gilles de la Tourette's disease, Friedreich's ataxia and pre-senile dementia. Preliminary data from various laboratories, including our own, in each of these disorders indicate that some clinical improvement can occasionally be seen, and that this approach deserves further investigation.
用膳食前体胆碱或卵磷脂替代中枢胆碱能系统不足的替代疗法。胆碱能缺乏状态可能存在于五种神经疾病中：亨廷顿舞蹈症、迟发性运动障碍、抽动秽语综合征、弗里德赖希共济失调和早老性痴呆。包括我们自己实验室在内的各个实验室针对这些疾病中的每一种所获得的初步数据表明，偶尔可以看到一些临床改善，并且这种方法值得进一步研究。
