Laxenaire M C, Chastel A, Borgo J, Kim K M, Medot A, Fossard J M, Barlier J
Ann Anesthesiol Fr. 1977;18(7-8):711-9.
To protect the organism against histamine liberated during anesthesia specific premedication is used including:--hydroxyzine (Atarax) which blocks the H1 histamine receptors, and is an anxiolytic,--tritoqualine (Hypostamine) which inhibits histamine synthesis,--epsilon aminocaproic acid (Hemocaprol) which prevents the antigen-antibody reaction and blocks the alternate route of complement. Twenty five patients were thus premedicated, 25 others received no premedication. All were put to sleep with Alfatesine. The results were judged on the clinical symptoms and the variations of histamine in whole blood. This premedication seems very efficacious, in particular in subjects with a high risk of histamine liberation.
为保护机体免受麻醉期间释放的组胺影响，使用了特定的术前用药，包括：——羟嗪（安他乐），可阻断组胺H1受体，具有抗焦虑作用；——三甲丙喹啉（抑胺），可抑制组胺合成；——ε-氨基己酸（抗血纤溶环酸），可防止抗原-抗体反应并阻断补体替代途径。25例患者接受了术前用药，另外25例未接受术前用药。所有患者均使用阿法他明诱导麻醉。根据临床症状和全血中组胺的变化来判断结果。这种术前用药似乎非常有效，尤其是对组胺释放风险较高的患者。
