Doenicke A, Lorenz W
Ann Anesthesiol Fr. 1977;18(7-8):691-700.
The authors studied in 270 volunteers histamine liberation after administration of drugs. Definite histamine liberation was noted after propanidide, pentothal, methohexital, Alfatesine, and also after muscle relaxants including pancuronium bromide. Until now, among all the substances studies, both clinically and in the laboratory, after 4 years, only etomidate, according to their personal experience is not a histamine liberator. Similar results were observed after ketamine, but also after administration of Atosil (Phenergan) fenestil (Dimethendène) and Trasylol (Zymofren). As far as plasma susbtitutes are concerned, the search for mediators of the anaphylactoid and anaphylactic reactions should be considered in a differential way.
作者对270名志愿者用药后组胺释放情况进行了研究。在使用丙泮尼地、硫喷妥钠、美索比妥、阿法西丁后，以及在包括泮库溴铵在内的肌肉松弛剂使用后，均观察到明确的组胺释放。迄今为止，根据他们的个人经验，在临床和实验室研究的所有物质中，经过4年观察，只有依托咪酯不是组胺释放剂。氯胺酮用药后也观察到类似结果，使用阿托西尔（异丙嗪）、费内斯蒂尔（二甲茚定）和抑肽酶（胰蛋白酶抑制剂）后同样如此。就血浆代用品而言，应区别考虑类过敏反应和过敏反应介质的研究。
