Healey M L, Dykstra L A
Pharmacol Biochem Behav. 1980 Sep;13(3):349-57. doi: 10.1016/0091-3057(80)90238-5.
Drug interactions were examined in pigeons keypecking under a multiple fixed ratio 30-response, fixed interval 5-minute (mult FR 30, FI 5-min) schedule of food presentation. Low to intermediate doses of d-amphetamine attenuated the rate-decreasing effects of ethanol under both components of the multiple schedule; however, these same doses of d-amphetamine seldom attenuated the rate-decreasing effects of pentobarbital. Increases in rates of responding produced by ethanol or pentobarbital under FI components were often enhanced following low to intermediate doses of d-amphetamine. Higher doses of d-amphetamine generally enhanced the rate-decreasing effects produced by either ethanol or pentobarbital alone. Results indicate that the joint effects of two drugs cannot be predicted from a knowledge of either their individual or their rate-dependent effects.
在鸽子按照多重固定比率30次啄击、固定间隔5分钟（多重FR 30，FI 5分钟）的食物呈现时间表进行啄击时，对药物相互作用进行了研究。低至中等剂量的右旋苯丙胺在多重时间表的两个组成部分下均减弱了乙醇的速率降低效应；然而，相同剂量的右旋苯丙胺很少减弱戊巴比妥的速率降低效应。在FI组成部分下，乙醇或戊巴比妥产生的反应速率增加在低至中等剂量的右旋苯丙胺之后通常会增强。较高剂量的右旋苯丙胺通常会增强单独使用乙醇或戊巴比妥所产生的速率降低效应。结果表明，两种药物的联合效应无法从对它们各自的或速率依赖性效应的了解中预测出来。
