Kulkosky P J
Pharmacol Biochem Behav. 1980 Sep;13(3):449-52. doi: 10.1016/0091-3057(80)90253-1.
Outbred male and female Wistar rats demonstrated large and consistent interindividual variations in nocturnal blood ethanol level (BEL) during ad lib access to food, water and an ethanol solution. Mean individual BEL ranged from 0--109 mg/dl, grand mean = 25.1 mg/dl (5.5 mM). BELs of all rats correlated with free-choice ethanol intakes, but females showed significantly greater ethanol intake (female and male means = 10.5 and 8.2 g/kg/24 hr) that was unaccompanied by significantly greater BEL (female and male means = 30.6 and 19.6 mg/dl). Across three linearly derived generations, progeny of rats matched for high BELs (mean = 25.1 mg/dl), but there was no significant difference across generations in ethanol intake (respective means = 8.4 and 8.1 g/kg/24 hr). In the third derived generation, there were significant differences between high and low BEL progeny in both BEL (respective means = 35 and 15 mg/dl) and ethanol intake (respective means = 8.2 and 6.3 g/kg/24 hr).
在自由获取食物、水和乙醇溶液的情况下，远交系雄性和雌性Wistar大鼠夜间血液乙醇水平（BEL）表现出个体间巨大且一致的差异。个体平均BEL范围为0 - 109mg/dl，总体平均值 = 25.1mg/dl（5.5mM）。所有大鼠的BEL与自由选择的乙醇摄入量相关，但雌性大鼠的乙醇摄入量显著更高（雌性和雄性平均值分别为10.5和8.2g/kg/24小时），而其BEL并未显著更高（雌性和雄性平均值分别为30.6和19.6mg/dl）。在三个线性衍生代中，BEL匹配较高（平均值 = 25.1mg/dl）的大鼠后代，但各代间乙醇摄入量无显著差异（各自平均值 = 8.4和8.1g/kg/24小时）。在第三代衍生代中，高BEL和低BEL后代在BEL（各自平均值 = 35和15mg/dl）和乙醇摄入量（各自平均值 = 8.2和6.3g/kg/24小时）方面均存在显著差异。
