在等金属硫蛋白水平下研究锌负荷对大鼠肝脏和肾脏中锌硫蛋白的诱导作用。

Induction of zinc-thionein in rat liver and kidneys by zinc loading as studied at isometallothionein levels.

作者信息

Suzuki K T, Yamamura M

出版信息

Toxicol Lett. 1980 Jun;6(1):59-65. doi: 10.1016/0378-4274(80)90103-4.

Abstract

Zinc acetate was injected i.p. into female rats to try to clarify the detailed induction and degradation pathways of zinc-thionein (Zn-th) at isometallothionein levels in liver and kidneys. Injected zinc in serum decreased with the induction of Zn-th in the liver and kidneys, and the amounts of Zn-th in both tissues attained maxima 24 h after injection. The relative ratios of isometallothioneins changed with time in both tissues. The changes are compared with those of cadmium (Cd) loading.

摘要

腹腔注射乙酸锌至雌性大鼠体内，以试图阐明肝脏和肾脏中金属硫蛋白水平下锌硫蛋白（Zn-th）的详细诱导和降解途径。随着肝脏和肾脏中Zn-th的诱导，血清中注射的锌减少，且两个组织中Zn-th的量在注射后24小时达到最大值。两个组织中异金属硫蛋白的相对比例均随时间变化。将这些变化与镉（Cd）负荷的变化进行比较。