大鼠尿液中代森锰锌代谢物排泄的剂量依赖性。
Dose dependence of the excretion of maneb metabolites in urine of rats.
作者信息
Brocker E R, Schlatter C
出版信息
Toxicol Lett. 1980 Sep;6(4-5):221-4. doi: 10.1016/0378-4274(80)90122-8.
PMID:7423549
Abstract
14C-activity in the urine of female rats appeared to be independent of dose when single oral doses of [14C]maneb, a fungicide, manganese ethylene-bis(dithiocarbamate), were given. This was found with [14C]maneb synthesized from [U-14C]ethylenediamine. In the dose range, 23 microgram/kg to 1.4 g/kg of maneb, the excreted activity in urine of 39 female rats was 48.8 +/- 12.6% (n=39).
摘要
当给雌性大鼠单次口服杀菌剂[14C]代森锰（锰乙撑双二硫代氨基甲酸盐）时，其尿液中的14C活性似乎与剂量无关。这一现象在由[U-14C]乙二胺合成的[14C]代森锰中得到证实。在23微克/千克至1.4克/千克代森锰的剂量范围内，39只雌性大鼠尿液中的排泄活性为48.8±12.6%（n=39）。
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