Meco G, Bonifati V, Vanacore N, Fabrizio E
Department of Neurosciences, La Sapienza University, Rome, Italy.
Scand J Work Environ Health. 1994 Aug;20(4):301-5. doi: 10.5271/sjweh.1394.
Permanent parkinsonism was observed in a man with chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). Symptoms developed at 37 years of age, two years after exposure had ceased. To our knowledge, this is the second report on parkinsonism associated with exposure to maneb. Manganese is a well-known parkinsonigen toxin in humans. More recently, it has been shown that dithiocarbamates can also induce extrapyramidal syndromes. The biochemical effects of manganese and dithiocarbamates are reviewed and their possible neurotoxic mechanisms are discussed. Both of these components may have played a role in this case.
一名长期接触杀菌剂代森锰（锰乙烯双二硫代氨基甲酸盐）的男子出现了永久性帕金森症。症状在37岁时出现，接触停止两年后发病。据我们所知，这是第二例与接触代森锰相关的帕金森症报告。锰是一种已知的可导致人类患帕金森症的毒素。最近有研究表明，二硫代氨基甲酸盐也可诱发锥体外系综合征。本文综述了锰和二硫代氨基甲酸盐的生化作用，并讨论了它们可能的神经毒性机制。在这个病例中，这两种成分可能都起了作用。
