大鼠对膳食中丁基羟基甲苯的排泄情况。

Excretion of dietary butylated hydroxytoluene by the rat.

作者信息

Takahashi O, Hiraga K

出版信息

Toxicol Lett. 1980 Sep;6(4-5):287-92. doi: 10.1016/0378-4274(80)90133-2.

Abstract

The concentration of phenols in the urine or feces of rats receiving a diet containing 1.00% butylated hydroxytoluene (BHT) for 10 days was determined colorimetrically. The cumulative intake of BHT was approx. 5.0 mmol/rat for 10 days. The total amount of phenols excreted in urine and feces was 3.65 mmol/rat for 10 days, i.e. 73% of the administered BHT. About 48% was excreted in the urine, and 25% in the feces; about 30%, or 11%, of the dose appeared to be present as unconjugated phenols in the urine, or feces, respectively. The major metabolite detected was 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHT acid).

摘要

采用比色法测定了连续10天摄入含1.00%丁基化羟基甲苯（BHT）日粮的大鼠尿液和粪便中酚类物质的浓度。10天内BHT的累积摄入量约为5.0 mmol/只大鼠。10天内尿液和粪便中排出的酚类物质总量为3.65 mmol/只大鼠，即摄入BHT的73%。约48%经尿液排出，25%经粪便排出；给药剂量的约30%或11%分别以未结合酚的形式存在于尿液或粪便中。检测到的主要代谢产物是3,5 - 二叔丁基 - 4 - 羟基苯甲酸（BHT酸）。