[Investigations of combined injuries, 28th communication: Troubles of hemostatic equilibrium arising from radiation and combined injuries (author's transl)].

In female mice the influence of total-body irradiation combined with excision of skin on the blood-clotting system was examined. Whereas the general tests of plasmatic coagulation showed no significant change, a biphasic course of coagulation disturbances in thrombelastography and euglobulin-clot-lysis following combined radiation injury was found. During the first time a pronounced increase of coagulability appeared, followed by the development of a hypocoagulability due to thrombocytopenia and functional disturbances of blood platelets. In this hemorrhagic period the euglobulin-clotlysis time was accelerated, but only after combined injury. Possible reasons are discussed.