Filippova L B, Rozanov A Ia
Vopr Med Khim. 1980 Sep-Oct;26(5):643-6.
35S-Hemineurine penetrated across the blood-brain barrier more rapidly than 35S-thiamin within the first 30 min after intravenous administration. Within 24 hrs content of 35S-thiamin in the neurones exceeded by 34% its concentration in glia and by 200% -- in myelin fraction. 35S-Hemineurine was bound slightly with brain proteins as compared with thiamin and it was removed at the higher rate from brain regions and subcellular structures.
静脉注射后最初30分钟内,35S-半硫胺素穿过血脑屏障的速度比35S-硫胺素更快。24小时内,神经元中35S-硫胺素的含量比神经胶质细胞中的浓度高34%,比髓磷脂部分高200%。与硫胺素相比,35S-半硫胺素与脑蛋白的结合较弱,并且从脑区和亚细胞结构中清除的速度更快。