Lembcke B, Hönig M, Caspary W F
Z Gastroenterol. 1980 Mar;18(3):155-60.
Purpose of this investigation was to characterize the effect of antibiotics as a possible limiting factor for the evaluation of hydrogen (H2) breath analysis tests which depend on bacterial carbohydrate fermentation. Breath H2-excretion following ingestion of the non-absorbable disaccharide lactulose was monitored in healthy subjects before and after pretreatment with the aminoglycoside neomycin or with metronidazole. Metronidazole decreased the amount of hydrogen exhaled by 39 % (p<0.05) and peak H2-excretion by 42.1 % (p<0.01), because it suppresses anaerobe H2 producing microorganisms. Neomycin intensified nonsignificantly the integrated (0-6 hours) breath hydrogen response to lactulose (+43 %) and the maximal H2-concentration by 29.8 %, probably because it interferes with intestinal bacteria which are important for H2-consumption.
本研究的目的是确定抗生素作为一种可能的限制因素，对依赖细菌碳水化合物发酵的氢气（H2）呼气分析测试评估的影响。在健康受试者中，用氨基糖苷类新霉素或甲硝唑预处理前后，监测摄入不可吸收双糖乳果糖后的呼气H2排泄情况。甲硝唑使呼出的氢气量减少了39%（p<0.05），使H2排泄峰值减少了42.1%（p<0.01），因为它抑制了产生H₂ 的厌氧微生物。新霉素使对乳果糖的累积（0 - 6小时）呼气氢气反应（增加43%）和最大H₂ 浓度（增加29.8%）略有增强，这可能是因为它干扰了对H₂ 消耗很重要的肠道细菌。
