Wilberg S, Pieramico O, Malfertheiner P
Abteilung Innere Medizin II, Universitätsklinik Ulm.
Leber Magen Darm. 1990 May;20(3):129-37.
The H2-Lactulose breath test is used to detect small bowel bacterial overgrowth but mainly to evaluate the orocoecal transit time (OCTT) in man. The result of the H2-breath test is influenced by several intestinal and extraintestinal factors that cause a large variability of normal values. By reviewing the possible influencing factors of the breath tests we try to make a contribution to a better judgement of the results as the H2-lactulose breath-test is a simple noninvasive and non-expensive screening in the investigation of gastrointestinal disorders. For evaluating the better dosage of lactulose in gastroenterological routine diagnostic we designed a prospective study. The test was performed in 12 healthy volunteers by ingestion of 10 g and 20 g lactulose to quantitate the OCTT and to evaluate it in normal conditions. We found that the length of transit is related to the dose of lactulose. OCTT was 97.1 +/- 22.4 min. after ingestion of 10 g lactulose, and significantly shorter, 57.1 +/- 16.6 min. after ingestion of 20 g lactulose (p less than or equal to 0.01). The lower dose of lactulose is more suitable for routine diagnostic because of better acceptance despite slower transit time.
氢呼气试验用于检测小肠细菌过度生长，但主要用于评估人体的口盲肠传输时间（OCTT）。氢呼气试验的结果受多种肠道和肠道外因素影响，这些因素导致正常值存在很大差异。通过回顾呼气试验可能的影响因素，我们试图为更好地判断结果做出贡献，因为氢呼气试验是胃肠道疾病调查中一种简单、无创且廉价的筛查方法。为了评估胃肠病学常规诊断中乳果糖的更佳剂量，我们设计了一项前瞻性研究。该试验在12名健康志愿者中进行，通过摄入10克和20克乳果糖来定量OCTT并在正常条件下进行评估。我们发现传输时间的长短与乳果糖剂量有关。摄入10克乳果糖后，OCTT为97.1±22.4分钟，而摄入20克乳果糖后明显更短，为57.1±16.6分钟（p≤0.01）。较低剂量的乳果糖更适合常规诊断，因为尽管传输时间较慢，但接受度更好。
