Becker P, Zunker M
Zentralbl Bakteriol A. 1980 Aug;247(3):290-5.
To resolve the problem by which route rabies virus is migrating within the infected organism, coelioanastomosis was performed by operating two albino rats each so that a connection between blood vessels, however not between nerves was established. One of the partners was infected in each case. As soon as one of the parabionts exhibited specific disease, the animals were disconnected again. A comparison of street virus and strains of virus fixé that had been maintained by intracerebral, plantar, and intramuscular passage revealed basic differences. Street virus was found to be transmitted to the non-infected partner almost regularly while virus fixé maintained by intracerebral passage almost never was transmitted. After i.m. passages, plantar virus held an intermediate position.
为了解决狂犬病病毒在受感染机体中通过何种途径迁移的问题，对两只白化大鼠进行手术，建立血管吻合但不建立神经吻合。每种情况下均感染其中一只大鼠。一旦联体动物中的一只出现特定疾病，就再次将动物分开。对街毒株和通过脑内、足底和肌肉传代保存的固定毒株进行比较，发现了基本差异。结果发现，街毒株几乎能定期传播给未感染的联体伙伴，而通过脑内传代保存的固定毒株几乎从不传播。经肌肉传代后，足底病毒处于中间位置。
