Kaufman H H, Anderson J H, Woo J, Huchton J D, Cannon D C
Acta Neurochir (Wien). 1980;52(3-4):185-94. doi: 10.1007/BF01402073.
Embolus radiolabelling with 131I fibrinogen was studied in a canine model of internal carotid artery embolization. The dog was chosen as the experimental animal because of its maxillocarotid artery which permits collateral flow round the occlusion and helps to prevent strokes. Clot was prepared by incubating blood at room temperature to inactivate plasminogen activators and then refrigerating it to promote clot retraction. Emboli persisting 48 hours were seen in 80% of animals. Major strokes were not seen when 0.25 to 0.30 cm3 were used. Autoradiography and well counting revealed uptake of isotope. The test, when refined, should provide a tool for the investigation of thromboemboli.
在犬类颈内动脉栓塞模型中研究了用¹³¹I纤维蛋白原进行栓子放射性标记。选择狗作为实验动物是因为其颌颈动脉，它允许在闭塞周围有侧支血流并有助于预防中风。通过在室温下孵育血液以使纤溶酶原激活剂失活，然后冷藏以促进凝块收缩来制备凝块。80%的动物中可见栓子持续48小时。当使用0.25至0.30立方厘米时未观察到严重中风。放射自显影和井型计数显示有同位素摄取。该测试经过改进后应可为血栓栓塞的研究提供一种工具。
