Kobayashi R H, Hyman C J, Stiehm E R
Am J Dis Child. 1980 Oct;134(10):942-4. doi: 10.1001/archpedi.1980.02130220020006.
An infant born to a mother with agammaglobulinemia was followed up since birth to study immunologic maturation uninfluenced by circulating maternal antibodies. Immunoglobulin levels remained low and antibodies to immunizing antigens appeared late. These observations, together with findings in two other reported infants born to agammaglobulinemic mothers, suggest that transplacental maternal antibodies play little or no role in modulating newborn igG production and that the delay in achieving normal levels of IgG are probably due to the immaturity of newborn B lymphocytes.
对一位患有丙种球蛋白血症母亲所生的婴儿自出生起进行随访，以研究不受循环母体抗体影响的免疫成熟情况。免疫球蛋白水平持续较低，对免疫抗原的抗体出现较晚。这些观察结果，连同另外两名报道的患有丙种球蛋白血症母亲所生婴儿的研究结果，表明经胎盘的母体抗体在调节新生儿IgG产生中作用很小或没有作用，且新生儿IgG达到正常水平的延迟可能是由于新生儿B淋巴细胞不成熟所致。
