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惊恐障碍家系的遗传学研究。

A genetic study of panic disorder pedigrees.

作者信息

Pauls D L, Bucher K D, Crowe R R, Noyes R

出版信息

Am J Hum Genet. 1980 Sep;32(5):639-44.

PMID:7424907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1686098/
Abstract

Pedigree analysis is done on 19 kindreds of panic disorder, and the results suggest that this disorder is transmitted as an autosomal dominant trait. Seven of these 19 kindreds were ascertained through a panic disorder proband with mitral valve prolapse. When the analysis is done omitting these seven kindreds, the results also suggest that panic disorder without prolapse is transmitted as an autosomal dominant trait.

摘要

对19个惊恐障碍家系进行了系谱分析,结果表明该障碍以常染色体显性性状传递。这19个家系中有7个是通过患有二尖瓣脱垂的惊恐障碍先证者确定的。当分析时排除这7个家系,结果也表明无脱垂的惊恐障碍以常染色体显性性状传递。

相似文献

1
A genetic study of panic disorder pedigrees.惊恐障碍家系的遗传学研究。
Am J Hum Genet. 1980 Sep;32(5):639-44.
2
Distribution of ancestral secondary cases in anxiety neurosis (panic disorder).焦虑性神经症(惊恐障碍)中祖传继发病例的分布情况。
J Affect Disord. 1979 Dec;1(4):387-90.
3
Mitral valve prolapse and thyroid abnormalities in patients with panic attacks.惊恐发作患者的二尖瓣脱垂与甲状腺异常
Am J Psychiatry. 1987 Apr;144(4):493-6. doi: 10.1176/ajp.144.4.493.
4
Mitral valve prolapse, panic disorder, and chest pain.二尖瓣脱垂、惊恐障碍与胸痛。
Med Clin North Am. 1991 Sep;75(5):1119-33. doi: 10.1016/s0025-7125(16)30402-3.
5
Mitral valve prolapse and panic disorder.二尖瓣脱垂与惊恐障碍。
Psychiatr Clin North Am. 1985 Mar;8(1):63-71.
6
Low prevalence of mitral valve prolapse in patients with panic disorder.惊恐障碍患者二尖瓣脱垂的低患病率。
Am J Psychiatry. 1984 Feb;141(2):302-3. doi: 10.1176/ajp.141.2.302.
7
The prevalence of mitral valve prolapse in patients with panic disorders.惊恐障碍患者二尖瓣脱垂的患病率。
Am J Psychiatry. 1986 Apr;143(4):511-5. doi: 10.1176/ajp.143.4.511.
8
Prevalence of anxiety disorders in patients with mitral valve prolapse.二尖瓣脱垂患者中焦虑症的患病率。
Am J Psychiatry. 1986 Mar;143(3):349-52. doi: 10.1176/ajp.143.3.349.
9
Panic disorder: its association with mitral valve prolapse and appropriate dental management.惊恐障碍:其与二尖瓣脱垂的关联及适当的牙科治疗
Oral Surg Oral Med Oral Pathol. 1987 Mar;63(3):309-12. doi: 10.1016/0030-4220(87)90195-2.
10
Mitral valve prolapse, panic states, and anxiety. A dilemma in perspective.二尖瓣脱垂、惊恐状态与焦虑。透视中的一个困境。
Psychiatr Clin North Am. 1987 Mar;10(1):141-50.

引用本文的文献

1
Panic disorders: The role of genetics and epigenetics.惊恐障碍:遗传学与表观遗传学的作用
AIMS Genet. 2018 Jul 27;5(3):177-190. doi: 10.3934/genet.2018.3.177. eCollection 2018.
2
Are there anxious genes?存在焦虑基因吗?
Dialogues Clin Neurosci. 2002 Sep;4(3):251-60. doi: 10.31887/DCNS.2002.4.3/dmrosendahl.
3
Trials of structural exploratory data analysis.结构探索性数据分析试验。
Am J Hum Genet. 1982 May;34(3):489-500.
4
A controlled study of Tourette syndrome. III. Phobias and panic attacks.抽动秽语综合征的对照研究。III. 恐惧症与惊恐发作
Am J Hum Genet. 1987 Nov;41(5):761-81.
5
The utility of the panic disorder concept.惊恐障碍概念的效用。
Eur Arch Psychiatry Neurol Sci. 1989;238(5-6):268-79. doi: 10.1007/BF00449808.

本文引用的文献

1
Heredity in the Psychoneuroses (Summary).神经官能症中的遗传因素(总结)
Proc R Soc Med. 1942 Oct;35(12):785-90. doi: 10.1177/003591574203501215.
2
Observations on Heredity in Neurosis: (Section of Psychiatry).神经症遗传观察:(精神病学部分)
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Am J Hum Genet. 1951 Jun;3(2):126-58.
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A family study of anxiety neurosis. Morbidity risk in families of patients with and without mitral valve prolapse.焦虑症的家族研究。有和没有二尖瓣脱垂患者家庭中的发病风险。
Arch Gen Psychiatry. 1980 Jan;37(1):77-9. doi: 10.1001/archpsyc.1980.01780140079008.
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6
Anxiety states (anxiety neurosis): a review.焦虑状态(焦虑神经症):综述
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7
The evidence for genetic components in the neuroses. A review.神经症中遗传因素的证据。综述。
Arch Gen Psychiatry. 1973 Jul;29(1):111-8. doi: 10.1001/archpsyc.1973.04200010080014.
8
Echocardiographic detection of mitral valve prolapse. Exclusion of false positive diagnosis and determination of inheritance.超声心动图检测二尖瓣脱垂。排除假阳性诊断并确定遗传情况。
Circulation. 1975 Dec;52(6):1091-6. doi: 10.1161/01.cir.52.6.1091.
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General models for segregation analysis.分离分析的一般模型。
Am J Hum Genet. 1975 Jan;27(1):31-45.
10
The family history method using diagnostic criteria. Reliability and validity.采用诊断标准的家族史方法。可靠性与有效性。
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