Buscema J, Woodruff J D
Am J Obstet Gynecol. 1980 Sep 15;138(2):146-50. doi: 10.1016/0002-9378(80)90025-3.
Identification of the patient at risk for the development of cancer and the precursory histopathologic changes has led to improvement in 5-year survivals among patients with cancer of the cervix and endometrium. In conrast, there has been controversy as to these factors in discussions of vulvar neoplasia. This report of five cases of patients who developed invasive cancer after treatment for in situ disease attempts to define some of the at-risk factors, including the specific area at which three of the five malignancies subsequently developed.
识别有患癌风险的患者以及癌前组织病理学变化，已使宫颈癌和子宫内膜癌患者的5年生存率有所提高。相比之下，在外阴肿瘤的讨论中，关于这些因素一直存在争议。本报告介绍了5例原位疾病治疗后发生浸润癌的患者，试图确定一些风险因素，包括5例恶性肿瘤中有3例随后发生的具体部位。
