May P R, Van Putten T, Yale C
Am J Psychiatry. 1980 Sep;137(9):1088-9. doi: 10.1176/ajp.137.9.1088.
The authors gave 48 newly admitted schizophrenic patients an initial test dose (2.2 mg/kg) of chlorpromazine hydrochloride and additional doses at 24 and 36 hours. Clinical response was measured at 48 hours and at the end of subsequent treatment with a fixed dose (6.6 mg/kg) of chlorpromazine. There was a consistent correlation between 48-hour change and the eventual amount of improvement by the end of drug treatment for all 10 outcome criteria. The authors conclude that change early on in drug treatment is a useful predictor of outcome.
作者给48名新入院的精神分裂症患者初始剂量（2.2毫克/千克）的盐酸氯丙嗪，并在24小时和36小时给予额外剂量。在48小时时以及随后用固定剂量（6.6毫克/千克）的氯丙嗪治疗结束时测量临床反应。对于所有10项结果标准，48小时时的变化与药物治疗结束时最终的改善程度之间存在一致的相关性。作者得出结论，药物治疗早期的变化是结果的一个有用预测指标。
