Malkinson F D, Levitt L
Arch Dermatol. 1980 Oct;116(10):1147-50.
Six patients with skin changes and urinary porphyrin excretion patterns characteristic for porphyria cutanea tarda were treated with hydroxychloroquine sulfate therapy. During treatment periods ranging from five to 13 months, cutaneous symptoms disappeared and urinary porphyrin excretion abnormalities were completely or almost completely reversed. In three subjects, hydroxychloroquine therapy was accompanied by changes in the urinary excretion of iron. The first four patients, followed up for nine to 24 months after treatment, all had relapse, and substantial porphyrinuria developed once more; cutaneous symptoms recurred in two of these. Three of the four patients were re-treated, and their conditions again improved or went into remission with hydroxychloroquine therapy. In two patients, treatment responses were slower than those initially seen, despite the use of higher drug doses; in the third patient, the response to re-treatment was more rapid than that seen during the first treatment course.
对6例患有迟发性皮肤卟啉病特征性皮肤改变和尿卟啉排泄模式的患者采用硫酸羟氯喹进行治疗。在为期5至13个月的治疗期间，皮肤症状消失，尿卟啉排泄异常完全或几乎完全逆转。在3名受试者中，羟氯喹治疗伴有铁尿排泄的变化。前4例患者在治疗后随访9至24个月，均复发，再次出现大量卟啉尿；其中2例皮肤症状复发。4例患者中的3例接受了再次治疗，他们的病情再次因羟氯喹治疗而改善或缓解。在2例患者中，尽管使用了更高剂量的药物，治疗反应仍比最初所见的慢；在第3例患者中，再次治疗的反应比第一个疗程更快。
