精神科患者血浆中游离及结合型 3-甲氧基-4-羟基苯乙二醇的初步研究

Plasma free and conjugated MHPG in psychiatric patients. A pilot study.

作者信息

Sweeney D R, Leckman J F, Maas J W, Hattox S, Heninger G R

出版信息

Arch Gen Psychiatry. 1980 Oct;37(10):1100-3. doi: 10.1001/archpsyc.1980.01780230018002.

DOI:10.1001/archpsyc.1980.01780230018002

Abstract

Measures of plasma 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) may be useful for investigating noradrenergic function in certain behavioral and physiologic states. Serial plasma and urine samples were obtained from a diagnostically heterogeneous group of ten psychiatric inpatients over a three- to five-day period. The plasma samples were assayed for free and total MHPG and the urine samples for total MPHG. The variance between patients in both plasma free and conjugated MHPG was markedly greater than the variance within patients. The test-retest reliability for free plasma MHPG in both AM vs PM values within and across study days was also significant for both free and conjugated MHPG even though the AM plasma free MHPG values were significantly greater than the PM values. No significant correlations were found between plasma free and conjugated MHPG or between urinary total MHPG and plasma free MHPG.

摘要

血浆3-甲氧基-4-羟基苯乙二醇（MHPG）的检测方法可能有助于研究某些行为和生理状态下的去甲肾上腺素能功能。在三到五天的时间里，从一组诊断各异的十名精神科住院患者中采集了系列血浆和尿液样本。检测血浆样本中的游离和总MHPG，以及尿液样本中的总MPHG。患者之间血浆游离和结合型MHPG的差异明显大于患者自身内部的差异。即使上午血浆游离MHPG值显著高于下午值，但在研究日内和不同研究日之间，上午与下午血浆游离MHPG值的重测信度对于游离和结合型MHPG均具有显著性。血浆游离和结合型MHPG之间，或尿总MHPG与血浆游离MHPG之间均未发现显著相关性。