细胞毒性药物对人工肺转移的增强作用。
Enhancement by cytotoxic agents of artificial pulmonary metastasis.
作者信息
Steel G G, Adams K
出版信息
Br J Cancer. 1977 Dec;36(6):653-8. doi: 10.1038/bjc.1977.247.
Abstract
The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells.
摘要
通过静脉注射将Lewis肺癌细胞接种于同基因受体小鼠体内，预先用环磷酰胺处理小鼠可显著增强肺部集落的形成。肺部克隆效率与环磷酰胺剂量呈线性关系，最佳处理时间为注射肿瘤细胞前2 - 4天。所形成的肺部集落大小分布与未处理受体中的集落相似。博来霉素、局部胸部照射和全身照射在提高肺部克隆效率方面效果要差得多。环磷酰胺还提高了肌肉注射植入肿瘤细胞的接种成功率。
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