Angelico M, Angelico F, Amodeo P, Attili A F, Puoti C, Ricci G, Capocaccia L
Atherosclerosis. 1980 Oct;37(2):293-9. doi: 10.1016/0021-9150(80)90015-5.
Fasting serum concentrations of the individual bile acids were measured by gas chromatography in 27 patients with primary hyperlipoproteinemia (8 type IIa, 7 type IIb and 12 type IV) and in 14 healthy subjects. Total serum bile acid levels were 1618 +/- 244 ng/ml (SE) in type IIa, 1296 +/- 251 ng/ml in type IIb and 15609 +/- 263 ng/ml in type IV hyperlipoproteinemia. These values did not differ significantly from values in the control group (1505 +/- 200 ng/ml). Serum levels of cholic acid were significantly higher in patients with type IIa (551 +/- 78 ng/ml) than in those with type IIb (190 +/- 57 ng/ml, P < 0.01) and type IV (240 +/- 57 ng/ml, P < 0.02), while intermediate values were recorded in the control group (384 +/- 49 ng/ml). Ursodeoxycholic acid was found in larger amounts in hyperlipidemic patients than in controls. No significant differences with respect to other bile acids were observed between the groups examined. According to the current concepts on the enterohepatic circulation of bile acids, the findings support the hypothesis that the intestinal absorption of cholic acid may differ in various types of hyperlipoproteinemia.
采用气相色谱法测定了27例原发性高脂血症患者（8例IIa型、7例IIb型和12例IV型）及14名健康受试者空腹血清中各胆汁酸的浓度。IIa型高脂血症患者血清总胆汁酸水平为1618±244 ng/ml（标准误），IIb型为1296±251 ng/ml，IV型高脂血症为15609±263 ng/ml。这些值与对照组（1505±200 ng/ml）相比无显著差异。IIa型患者的胆酸血清水平（551±78 ng/ml）显著高于IIb型患者（190±57 ng/ml，P<0.01）和IV型患者（240±57 ng/ml，P<0.02），而对照组为中间值（384±49 ng/ml）。高脂血症患者体内的熊去氧胆酸含量高于对照组。在所检查的各组之间，未观察到其他胆汁酸有显著差异。根据目前关于胆汁酸肝肠循环的概念，这些发现支持这样一种假说，即胆酸在不同类型的高脂血症中的肠道吸收可能有所不同。
