Stenvinkel P, Bárány P, Björkhem I, Einarsson K
Department of Renal Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Scand J Clin Lab Invest. 1990 May;50(3):337-41. doi: 10.3109/00365519009091588.
The fasting peripheral serum concentrations of cholic acid, chenodeoxycholic acid, deoxycholic acid and ursodeoxycholic acid were determined in a total of 32 patients with uraemia. Eighteen of the patients suffered from diarrhoea. A highly accurate and specific mass-fragmentographic technique with high sensitivity was used to measure the concentrations of the individual bile acids. The total amount of bile acids was normal in the two groups of patients. Patients with diarrhoea had 50% lower concentrations of deoxycholic acid than a corresponding group of healthy subjects. It is suggested that the low level of deoxycholic acid may contribute to diarrhoea in these patients.
对32例尿毒症患者测定了空腹外周血清中胆酸、鹅去氧胆酸、脱氧胆酸和熊去氧胆酸的浓度。其中18例患者有腹泻症状。采用一种高灵敏度、高精度且特异的质量碎片分析法来测定各胆汁酸的浓度。两组患者胆汁酸总量均正常。腹泻患者的脱氧胆酸浓度比相应的健康受试者组低50%。提示脱氧胆酸水平低可能是这些患者腹泻的原因。
